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phosphoinositide signaling diseases

Tuesday 15 June 2004

Phosphoinositides (PIs) play an essential role in diverse cellular functions. Their intracellular level is strictly regulated by specific phosphoinositides kinases, phosphoinositides phosphatases and phosphoinositides phospholipases.

Pathology

- PTEN-associted diseases
- Src homology 2-containing inositol-5-phosphatase phosphatases in acute myeloid leukemia or diabetes
- myotubularin family members in genetic diseases
- OCRL1 in Lowe syndrome

References

- Pendaries C, Tronchere H, Plantavid M, Payrastre B. Phosphoinositide signaling disorders in human diseases. FEBS Lett. 2003 Jul 3;546(1):25-31. PMID: 12829232