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BCR

MIM.151410 22q11.21

Monday 7 June 2004

Pathology

- BCR/ABL fusion gene in B-lineage acute lymphoblastic leukemia by t(9;22)(q34;q11)

- BCR expression is decreased in meningiomas showing loss of heterozygosity of 22q (22q11 LOH) (18474292)

References

- Wozniak K, Piaskowski S, Gresner SM, Golanska E, Bieniek E, Bigoszewska K, Sikorska B, Szybka M, Kulczycka-Wojdala D, Zakrzewska M, Zawlik I, Papierz W, Stawski R, Jaskolski DJ, Och W, Sieruta M, Liberski PP, Rieske P. BCR expression is decreased in meningiomas showing loss of heterozygosity of 22q within a new minimal deletion region. Cancer Genet Cytogenet. 2008 May;183(1):14-20. PMID: 18474292

Reviews

- Giles FJ, Cortes JE, Kantarjian HM. Targeting the Kinase Activity of the BCR-ABL Fusion Protein in Patients with Chronic Myeloid Leukemia. Curr Mol Med. 2005 Nov;5(7):615-23. PMID: 16305488

- Ren R. Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer. 2005 Mar;5(3):172-83. PMID: 15719031