NTRK3

Definition: TrkC is a member of the Trk family of tyrosine kinase receptors and plays an important role in the development and maintenance of neural tissues.

Pathology

 ETV6-NTRK3 fusion gene by translocation t(12;15)(p13;q25)

• congenital fibrosarcoma (9462753)
• mesoblastic nephroma (9811336, 9823307)
• chronic myeloid leukemia
• secretory breast carcinoma (15101049)

 NTRK3 signaling is activated in adenoid cystic carcinoma and requires NT-3 to stimulate invasive behavior. (23027130)

 NTRK3 fusion genes in fibrosarcomas (30520818)

• NTRK fusions in malignant tumors are therapeutic targets of tyrosine kinase inhibitors.
• CD34-positive fibrosarcoma of bone and soft tissue could be a good candidate for NTRK testing.
• STRN-NTRK3 and STRN3-NTRK fusion genes

See also

 NTRKs

References

 Hisaoka M, Sheng WQ, Tanaka A, Hashimoto H. Gene expression of TrkC (NTRK3) in human soft tissue tumours. J Pathol. 2002 Aug;197(5):661-7. PMID: 12210087