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NTRK3
Thursday 3 June 2004
TrkC; TRKC
Definition: TrkC is a member of the Trk family of tyrosine kinase receptors and plays an important role in the development and maintenance of neural tissues.
Pathology
ETV6-NTRK3 fusion gene by translocation t(12;15)(p13;q25)
- congenital fibrosarcoma (9462753)
- mesoblastic nephroma (9811336, 9823307)
- chronic myeloid leukemia
- secretory breast carcinoma (15101049)
NTRK3 signaling is activated in adenoid cystic carcinoma and requires NT-3 to stimulate invasive behavior. (23027130)
NTRK3 fusion genes in fibrosarcomas (30520818)
- NTRK fusions in malignant tumors are therapeutic targets of tyrosine kinase inhibitors.
- CD34-positive fibrosarcoma of bone and soft tissue could be a good candidate for NTRK testing.
- STRN-NTRK3 and STRN3-NTRK fusion genes
See also
References
Hisaoka M, Sheng WQ, Tanaka A, Hashimoto H. Gene expression of TrkC (NTRK3) in human soft tissue tumours. J Pathol. 2002 Aug;197(5):661-7. PMID: 12210087