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CREB3L2

MIM.608834 16p11

Thursday 3 June 2004

CREB3L2 was first identified as the 3’-partner of FUS in a fusion gene that seems to be specific for low grade fibromyxoid sarcoma.

In silico analyses suggest that the predicted CREB3L2 protein is a member of the CREB3 family of transcription factors, with its bZIP domain being highly similar to that in CREB3L1, CREB3L3, CREB3L4, CREB3, and Drosophila Bbf-2.

Pathology

- FUS/CREB3L2 (or FUS/BBF2H7) fusion gene by t(7;16)(q33;p11) (CREB3L2 at 7q33 amd FUS at 16p11) in low-grade fibromyxoid sarcoma (#12915480#, #15139001#)

References

- DNA-based polymerase chain reaction for detecting FUS-CREB3L2 in low-grade fibromyxoid sarcoma using formalin-fixed, paraffin-embedded tissue specimens. Matsuyama A, Hisaoka M, Shimajiri S, Hashimoto H. Diagn Mol Pathol. 2008 Dec;17(4):237-40. PMID: #18382348#

- Panagopoulos I, Moller E, Dahlen A, Isaksson M, Mandahl N, Vlamis-Gardikas A, Mertens F. Characterization of the native CREB3L2 transcription factor and the FUS/CREB3L2 chimera. Genes Chromosomes Cancer. 2007 Feb;46(2):181-91. PMID: #17117415#

- Matsuyama A, Hisaoka M, Shimajiri S, Hayashi T, Imamura T, Ishida T, Fukunaga M, Fukuhara T, Minato H, Nakajima T, Yonezawa S, Kuroda M, Yamasaki F, Toyoshima S, Hashimoto H. Molecular detection of FUS-CREB3L2 fusion transcripts in low-grade fibromyxoid sarcoma using formalin-fixed, paraffin-embedded tissue specimens. Am J Surg Pathol. 2006 Sep;30(9):1077-84. PMID: #16931951#

- Panagopoulos I, Tiziana Storlazzi C, Fletcher CD, Fletcher JA, Nascimento A, Domanski HA, Wejde J, Brosjo O, Rydholm A, Isaksson M, Mandahl N, Mertens F. The chimeric FUS/CREB3l2 gene is specific for low-grade fibromyxoid sarcoma. Genes Chromosomes Cancer. 2004 Jul;40(3):218-28. PMID: 15139001

- Storlazzi CT, Mertens F, Nascimento A, Isaksson M, Wejde J, Brosjo O, Mandahl N, Panagopoulos I. Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma. Hum Mol Genet. 2003 Sep 15;12(18):2349-58. PMID: #12915480#