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lysophosphatidic acid

Monday 31 May 2004

The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation, migration and survival by acting on its cognate G-protein-coupled receptors.

Aberrant LPA production, receptor expression and signalling probably contribute to cancer initiation, progression and metastasis.

See also

- lysophospholipids

References

- Mills GB, Moolenaar WH. The emerging role of lysophosphatidic acid in cancer. Nat Rev Cancer. 2003 Aug;3(8):582-91. PMID: #12894246#