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mesoblastic nephromas

Thursday 19 June 2003

Variants

- classic mesoblastic nephroma
- cellular mesoblastic nephroma
- multicystic mesoblastic nephroma (1332189, 11927972)
- myoid differentiation (12149722)

Associations

- Beckwith-Wiedemann syndrome (9302166)

Cytogenetics

- trisomy 11 (17639583)
- translocation t(12-15)(p13;q25) creating ETV6/NTRK3 gene fusion in cellular mesoblastic nephroma

Molecular biology

- elevated expression levels of IGF2 mRNA in congenital mesoblastic nephroma of the cellular or mixed type with trisomy 11 (17639583)

- ETV6/NTRK3 gene fusion by t(12-15)(p13;q25) in cellular mesoblastic nephroma

  • formation of the chimeric protein tyrosine kinase ETV6-NTRK3 by gene fusion

Evolution

- rare metatstasis (8385324)

See also

- Tumors

  • renal tumors
    • pediatric renal tumors

References

- Watanabe N, Haruta M, Soejima H, Fukushi D, Yokomori K, Nakadate H, Okita H, Hata JI, Fukuzawa M, Kaneko Y. Duplication of the paternal IGF2 allele in trisomy 11 and elevated expression levels of IGF2 mRNA in congenital mesoblastic nephroma of the cellular or mixed type. Genes Chromosomes Cancer. 2007 Oct;46(10):929-35. PMID: 17639583

- Congenital mesoblastic nephroma in a child with the Beckwith-Wiedemann syndrome. Sutherland RW, Wiener JS, Hicks MJ, Hawkins EP, Chintagumpala M. J Urol. 1997 Oct;158(4):1532-3. PMID: 9302166

- Vujanic GM, Delemarre JF, Moeslichan S, Lam J, Harms D, Sandstedt B, Voute PA. Mesoblastic nephroma metastatic to the lungs and heart—another face of this peculiar lesion: case report and review of the literature. Pediatr Pathol. 1993 Mar-Apr;13(2):143-53. PMID: 8385324

- Vujanic GM. Congenital cystic mesoblastic nephroma: a rare cystic renal tumour of childhood. Case report. Scand J Urol Nephrol. 1992;26(3):315-7. PMID: 1332189