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CD1a

MIM.188370 1q21-q23

Sunday 30 May 2004

CD1a is a group-1 member of the CD1 family of major histocompatibility (MHC)-like glycoproteins.

CD1a is T cell surface antigen important in dendritic cell presentation of glycolipids and lipopeptide antigens.

CD1a may activate intrathyroidal T cells in Hashimoto’s thyroiditis and Grave’s disease (J Immunol 2005;174:3773)

Expression in normal cells

- Langerhans cells in normal skin
- CD1a+ cortical thymocytes in normal thymus
- immature dendritic cells (Langerin-, CD86-, HLA-DR low, CD40-low)

Expression in tumors

- Langerhans cell histiocytosis
- T-cell acute lymphoblastic leukemia (T-LLA)
- myeloid leukemias
- mycosis fungoides (variable)
- almost all cutaneous T cell lymphomas, T-ALL
- Barrett metaplasia of esophagus
- monocytes in most sickle cell anemia patients

Negative staining

- normal B cells
- dendritic cells in most cutaneous B cell lymphomas
- histiocytic lymphoma / sarcoma
- histiocytoma
- follicular dendritic cells
- follicular dendritic cell tumor
- interdigitating dendritic cells
- interdigitating dendritic cell sarcoma
- dendritic cell neurofibroma
- juvenile xanthogranuloma
- sinus histiocytosis with massive lymphadenopathy
- Erdheim-Chester disease

Portfolio

  • Cutaneous Langerhans histiocytosis CD1a+
  • Cutaneous Langerhans histiocytosis
  • Cutaneous Langerhans histiocytosis