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RNA regulation

Friday 28 May 2004

RNA regulons

Multiple mRNAs are co-regulated by one or more sequence-specific RNA-binding proteins that orchestrate their splicing, export, stability, localization and translation.

These and other observations have given rise to a model in which mRNAs that encode functionally related proteins are coordinately regulated during cell growth and differentiation as post-transcriptional RNA operons or regulons, through a ribonucleoprotein-driven mechanism.


- Keene JD. RNA regulons: coordination of post-transcriptional events. Nat Rev Genet. 2007 Jul;8(7):533-43. PMID: 17572691

- Mattick JS. RNA regulation: a new genetics? Nat Rev Genet. 2004 Apr;5(4):316-23. PMID: 15131654