Friday 28 May 2004
Microsatellites are unique highly polymorphic and informative genetic markers dispersed in the human genome.
Use in tumors
Microsatellites have become the most commonly used markers to trace loss of heterozygosity in tumors. Their detection by PCR is rapid and can be semi-automated with maximal robustness and reproducibility.
Ellegren H. Microsatellites: simple sequences with complex evolution. Nat Rev Genet. 2004 Jun;5(6):435-45. PMID: 15153996
Jin L, Baskett ML, Cavalli-Sforza LL, Zhivotovsky LA, Feldman MW, Rosenberg NA. Microsatellite evolution in modern humans: a comparison of two data sets from the same populations. Ann Hum Genet. 2000 Mar;64(Pt 2):117-34. PMID: 11246466