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microsatellites

Friday 28 May 2004

Microsatellites are unique highly polymorphic and informative genetic markers dispersed in the human genome.

Use in tumors

- Microsatellites have become the most commonly used markers to trace loss of heterozygosity in tumors. Their detection by PCR is rapid and can be semi-automated with maximal robustness and reproducibility.

References

- Ellegren H. Microsatellites: simple sequences with complex evolution. Nat Rev Genet. 2004 Jun;5(6):435-45. PMID: #15153996#

- Jin L, Baskett ML, Cavalli-Sforza LL, Zhivotovsky LA, Feldman MW, Rosenberg NA. Microsatellite evolution in modern humans: a comparison of two data sets from the same populations. Ann Hum Genet. 2000 Mar;64(Pt 2):117-34. PMID: #11246466#