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giant cell fibroblastoma

Friday 21 May 2004

Definition: Phenotypic variant of dermatofibrosarcoma protuberans (DFSP) sharing the same COL1A1/PDGFB fusion gene.


- Spindle and multinucleated giant cells in a loose myxoid stroma:


- giant cell fibroblastoma


- t(17;22)(q22;q13) creating COL1A1/PDGFB fusion protein

Molecular biology

- COL1A1-PDGFB fusion protein by t(17;22)(q22;q13) ( COL1A1 at 17q22 and PDGFB at 22q13 )

See also

- fusion genes
- fusion proteins