Home > A. Molecular pathology > TFEB

TFEB

MIM.600744 6p21

Thursday 20 May 2004

Molecular biology

- TFEB/MALAT1 fusion gene by t(6;11)(p21;q13) in

See also

- Oncobase

References

- Argani P, Lae M, Hutchinson B, Reuter VE, Collins MH, Perentesis J, Tomaszewski JE, Brooks JS, Acs G, Bridge JA, Vargas SO, Davis IJ, Fisher DE, Ladanyi M. Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR. Am J Surg Pathol. 2005 Feb;29(2):230-40. PMID: 15644781

- Argani, P.; Hawkins, A.; Griffin, C. A.; Goldstein, J. D.; Haas, M.; Beckwith, J. B.; Mankinen, C. B.; Perlman, E. J. : A distinctive pediatric renal neoplasm characterized by epithelioid morphology, basement membrane production, focal HMB45 immunoreactivity, and t(6;11)(p21.1;q12) chromosome translocation. Am. J. Path. 158: 2089-2096, 2001. PubMed ID : 11395386

- Davis, I. J.; Hsi, B.-L.; Arroyo, J. D.; Vargas, S. O.; Yeh, Y. A.; Motyckova, G.; Valencia, P.; Perez-Atayde, A. R.; Argani, P.; Ladanyi, M.; Fletcher, J. A.; Fisher, D. E. : Cloning of an alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation. Proc. Nat. Acad. Sci. 100: 6051-6056, 2003. PubMed ID : 12719541

- Kuiper, R. P.; Schepens, M.; Thijssen, J.; van Asseldonk, M.; van den Berg, E.; Bridge, J.; Schuuring, E.; Schoenmakers, E. F. P. M.; van Kessel, A. G. : Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution. Hum. Molec. Genet. 12: 1661-1669, 2003. PubMed ID : 12837690

Portfolio

  • TFEB positivity in HMB45+ renal cell tumor
  • TFEB positivity in HMB45+ renal cell tumor
  • TFEB positivity in HMB45+ renal cell tumor
  • TFEB positivity in HMB45+ renal cell tumor