Humpath.com - Human pathology

Home > E. Pathology by systems > Skin > desmoplastic trichoepithelioma

desmoplastic trichoepithelioma

Wednesday 5 May 2004

Synopsis

- cords/nests basaloid cells
- sclerotic stroma
- horn cysts with keratin

Images

- Desmoplastic trichoepithelioma

Differential diagnosis

- cutaneous slerodermiform basal cell carcinoma
- microcystic adnexal carcinoma (MAC)
- syringoma

Synopsis

- Combination of microcysts and thin strands of basaloid epithelium wrapped by collagen
- Microcysts
- Foci of calcification (calcifeid keratin)
- Small strands of epithelium occasionally wrapped by small collagen fibers.
- The epithelial component resembles the mantle portion of the follicle.
- Other follicular constituents may be present.
- Possible clusters of ghost cells (as in pilomatricoma)
- Possible clusters of basaloid cells with fibroblastic stroma

Differential diagnosis

- sclerosing epithelial neoplasms

  • morpheiform basal cell carcinoma
  • syringoma
  • microcystic adnexal carcinoma
  • desmoplastic basal cell carcinoma
  • microcystic adnexal carcinoma

- ghost cell cutaneous tumors

  • pilomatricoma

See also

- cutaneous follicular tumors
- desmoplastic lesions

Open References

- A case of desmoplastic trichoepithelioma with ossification. Wada M, Hanada K, Kanehisa F, Asai J, Takenaka H, Katoh N. Indian J Dermatol. 2013 Mar;58(2):164. doi : 10.4103/0019-5154.108112 PMID: 23716857 [Free]

- Diagnostic utility of immunohistochemistry in distinguishing trichoepithelioma and basal cell carcinoma: evaluation using tissue microarray samples. Tebcherani AJ, de Andrade HF Jr, Sotto MN. Mod Pathol. 2012 Oct;25(10):1345-53. doi : 10.1038/modpathol.2012.96 PMID: 22684216 [Free]

- Differentiation between basal cell carcinoma and trichoepithelioma by immunohistochemical staining of the androgen receptor: an overview. Arits AH, Van Marion AM, Lohman BG, Thissen MR, Steijlen PM, Nelemans PJ, Kelleners-Smeets NW. Eur J Dermatol. 2011 Nov-Dec;21(6):870-3. doi : 10.1684/ejd.2011.1504 PMID: 21865121 [Free]