giant cell hepatitis

Images

 https://twitter.com/Patholwalker/status/1616181742469255168

Etiology

 neonatal giant cell hepatitis
 post-infantile giant cell hepatitis
 infectious giant cell hepatitis

• viral hepatitis
  • cytomegalovirus hepatitis
  • rubella virus hepatitis
  • herpes simplex hepatitis
  • HPV
  • HHV-6 hepatitis
  • varicella hepatitis
  • coxsackievirus hepatitis
  • echovirus hepatitis
  • reovirus 3 hepatitis
  • parvovirus B19 hepatitis
  • HIV hepatitis
  • enterovirus hepatitis
  • paramyxovirus hepatitis
  • hepatitis A
  • hepatitis B
  • hepatitis C (rare)

• bacterial hepatitis
  • systemic bacterial sepsis
  • syphilis - syphilitic hepatitis
  • listeriosis hepatitis
  • tuberculosis (tuberculous hepatitis)

 parasitic hepatitis

• toxoplasmosis hepatitis

 cholestasis

• biliary atresia
• choledochal cyst
• bile duct paucity
• cystic fibrosis
• familial intrahepatic cholestatic syndromes
• bile acid synthetic disorders (inborn errors of bile acid synthesis)

 chromosomal anomalies

• trisomy 21
• trisomy 18
• monosomy X

 genetic metabolic disorders

• alpha-1-antitrypsin deficiency (1)
  -* galactosemia
• Niemann-Pick disease
• Gaucher disease
• mucolipidosis
• cerebrohepatorenal syndrome (Zellweger’s syndrome)
• acute tyrosinemia

 giant cell hepatitis with autoimmune hemolytic anemia (GCHAIHA)
 autoimmune hepatitis type II (LKM1+)
 erythematosus lupus (systemic lupus) ¸

According to age

 neonatal giant cell hepatitis
 infantile giant cell hepatitis
 postinfantile giant cell hepatitis

Associations

 neonatal hemochromatosis
 autoimmune hemolytic anemia (GCHAIHA)

See also

 hepatocytic giant cell transformation

References

 Neonatal giant cell hepatitis: histological and etiological findings. Torbenson M, Hart J, Westerhoff M, Azzam RK, Elgendi A, Mziray-Andrew HC, Kim GE, Scheimann A. Am J Surg Pathol. 2010 Oct;34(10):1498-503. PMID: 20871223