Home > G. Tumoral pathology > ALK+ anaplastic large cell lymphoma

ALK+ anaplastic large cell lymphoma

Monday 26 April 2004

ICD-9:200.6 ICD-0:M9714/3 eMedicine:1099272 MeSH:D017728

Digital Case

- HPC:190 : ALK+ anaplastic large cell lymphoma (ALK+ ALCL)
- HPC:341 : ALK+ anaplastic large cell lymphoma (ALK+ ALCL)

Synopsis

- 2%-7% of non-Hodgkin lymphomas

Immunochemistry

- CD30+
- EMA+ (50%)
- P53+

Variants

- monomorphic ALCL
- small cell ALCL
- lymphohistiocytic ALCL
- Hodgkin-like ALCL
- sarcomatoid ALCL
- neutrophil-rich ALCL
- eosinophil-rich ALCL
- signet-ring ALCL

Associations

- HIV infection

Differential diagnosis

- classic Hodgkin lymphoma

  • syncitial variant of sclerosing nodular Hodgkin lymphoma
  • lymphocyte depletion Hodkgkin lymphoma

- sinusoidal CD30-positive large B-cell lymphoma (10757332)
- HHV-8-associated lymphoma (15105661)
- Carcinomas
- melanoma

Molecular biology

- fusion genes invoving the ALK gene

  • NPM1/ALK fusion protein (70-80%) by t(2;5)(p23;q35)
  • TPM3/ALK fusion protein (20%) by t(1;2)(q25;p23)
  • MSN/ALK fusion protein by t(X;22)(q11;p23)
  • ATIC/ALK fusion protein by inv(2)(p23q35)
  • TFG/ALK fusion protein by t(2;3)(p23;q21)
  • CLTC/ALK fusion protein by t(2;17)(p23;q23)
  • ALO17/ALK fusion protein by t(2;17)(p23;q25)
  • MYH9/ALK fusion protein t(2;22)(p23;q11.2)

Links

- AGCOH

See also

- cutaneous CD30+ anaplastic large-cell lymphoma (cutaneous CD30+ ALCL)

References

- Anaplastic Large Cell Lymphoma Associated With Breast Implants: A Report of 13 Cases. Aladily TN, Medeiros LJ, Amin MB, Haideri N, Ye D, Azevedo SJ, Jorgensen JL, de Peralta-Venturina M, Mustafa EB, Young KH, You MJ, Fayad LE, Blenc AM, Miranda RN. Am J Surg Pathol. 2012 Jul;36(7):1000-1008. PMID: 22613996

- Vassallo J, Lamant L, Brugieres L, Gaillard F, Campo E, Brousset P, Delsol G. ALK-positive anaplastic large cell lymphoma mimicking nodular sclerosis Hodgkin’s lymphoma: report of 10 cases.Am J Surg Pathol. 2006 Feb;30(2):223-9. PMID: 16434897

- Allory Y, Merabet Z, Copie-Bergman C, Lange F, Yiou R, Gaulard P. Sarcomatoid variant of anaplastic large cell lymphoma mimics ALK-1-positive inflammatory myofibroblastic tumor in bladder. Am J Surg Pathol. 2005 Jun;29(6):838-9; PMID: 15897755

- Nakamura S, Shiota M, Nakagawa A, Yatabe Y, Kojima M, Motoori T, Suzuki R, Kagami Y, Ogura M, Morishima Y, Mizoguchi Y, Okamoto M, Seto M, Koshikawa T, Mori S, Suchi T. Anaplastic large cell lymphoma: a distinct molecular pathologic entity: a reappraisal with special reference to p80(NPM/ALK) expression. Am J Surg Pathol. 1997 Dec;21(12):1420-32. PMID: 9414185

Portfolio

  • t(2;5)(p23;q35) creating NPM1/ALK fusion protein