Home > A. Molecular pathology > proteasome inhibitors

proteasome inhibitors

Saturday 11 February 2006

Examples

- MG132

PAthology

- Multiple myeloma cells are unusually sensitive to inhibitors of the proteasome, a cellular organelle that specifically degrades unwanted and misfolded proteins, and proteasome inhibitor drugs have shown promise in patients.

References

- Jiang YH, Beaudet AL. Human disorders of ubiquitination and proteasomal degradation. Curr Opin Pediatr. 2004 Aug;16(4):419-26. PMID: #15273504#

- Ciechanover A, Ben-Saadon R. N-terminal ubiquitination: more protein substrates join in. Trends Cell Biol. 2004 Mar;14(3):103-6. PMID: #15055197#