Saturday 11 February 2006
Multiple myeloma cells are unusually sensitive to inhibitors of the proteasome, a cellular organelle that specifically degrades unwanted and misfolded proteins, and proteasome inhibitor drugs have shown promise in patients.
Ciechanover A, Ben-Saadon R. N-terminal ubiquitination: more protein substrates join in. Trends Cell Biol. 2004 Mar;14(3):103-6. PMID: 15055197