Thursday 22 April 2004
Although various functions of RNA are carried out in conjunction with proteins, some catalytic RNAs, or ribozymes, which contribute to a range of cellular processes, require little or no assistance from proteins.
Furthermore, the discovery of metabolite-sensing riboswitches and other types of RNA sensors has revealed RNA-based mechanisms that cells use to regulate gene expression in response to internal and external changes.
Structural studies have shown how these RNAs can carry out a range of functions. In addition, the contribution of ribozymes and riboswitches to gene expression is being revealed as far more widespread than was previously appreciated.
Serganov A, Patel DJ. Ribozymes, riboswitches and beyond: regulation of gene expression without proteins. Nat Rev Genet. 2007 Oct;8(10):776-90. PMID: #17846637#
Bagheri S, Kashani-Sabet M. Ribozymes in the age of molecular therapeutics. Curr Mol Med. 2004 Aug;4(5):489-506. PMID: #15267221#
Lewin AS, Hauswirth WW. Ribozyme gene therapy: applications for molecular medicine. Trends Mol Med. 2001 May;7(5):221-8. PMID: #11325634#