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loss of heterozygosity (LOH)

Wednesday 21 April 2004

Definition: In cells that carry a mutated allele of a tumour-suppressor gene, the gene becomes fully inactivated when the cell loses a large part of the chromosome carrying the wild-type allele. Regions with high frequency of LOH are believed to harbour tumour-suppressor genes.

Types

- fractional LOH (fractional allelic loss)

See also

- LOH study
- LOH regions
- LOH database in human tumors
- allelotyping
- laser capture microdissection and LOH
- clustering of minimal deleted regions

References

- Tomlinson IP, Lambros MB, Roylance RR. Loss of heterozygosity analysis: practically and conceptually flawed?
Genes Chromosomes Cancer. 2002 Aug;34(4):349-53. PMID: 12112523

- Thiagalingam S, Foy RL, Cheng KH, Lee HJ, Thiagalingam A, Ponte JF. Loss of heterozygosity as a predictor to map tumor suppressor genes in cancer: molecular basis of its occurrence. Curr Opin Oncol. 2002 Jan;14(1):65-72. PMID: 11790983

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