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AKTs

Wednesday 21 April 2004

Members of the AKT protein family (AKTs) are implicated in numerous biologic processes, including adipocyte and muscle differentiation, glycogen synthesis, glucose uptake, apoptosis, and cellular proliferation

The serine/threonine protein kinase AKT1 (also known as PKB, protein kinase B) is thought to be a key mediator of signal transduction processes. The identification of AKT1 substrates and the role AKT1 phosphorylation plays in regulating these molecules have been a major focus of research in recent years. AKT1 plays a key role in cancer progression by stimulating cell proliferation and inhibiting apoptosis and is also probably a key mediator of insulin signalling.

Members

AKT1 AKT2 AKT3

Pathways

- AKT-PIP3 signaling pathway
- Toll-like receptor pathways

References

- Kumar R, Hung MC. Signaling intricacies take center stage in cancer cells. Cancer Res. 2005 Apr 1;65(7):2511-5. PMID: 15805240

- Lawlor MA, Alessi DR. PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J Cell Sci. 2001 Aug;114(Pt 16):2903-10. PMID: 11686294

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