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caspase-independent cellular death

Tuesday 20 April 2004

- Caspase activation has been frequently viewed as synonymous with apoptotic cell death; however, caspases can also contribute to processes that do not culminate in cell demise. Moreover, inhibition of caspases can have cytoprotective effects.

- In a number of different models, caspase inhibition does not maintain cellular viability and instead shifts the morphology of death from apoptosis to nonapoptotic pathways.

See also

- caspases
- cell death
- apoptotic morphology
- cell death inhibition
- catabolic hydrolases
- mitochondrial membrane permeabilization

References

- Kroemer G, Martin SJ. Caspase-independent cell death. Nat Med. 2005 Jul;11(7):725-30. PMID: 16015365

- Abraham MC, Shaham S. Death without caspases, caspases without death. Trends Cell Biol. 2004 Apr;14(4):184-93. PMID: 15066636

- Mathiasen IS, Jaattela M. Triggering caspase-independent cell death to combat cancer. Trends Mol Med. 2002 May;8(5):212-20. PMID: 12067630