caspase-independent cellular death
Tuesday 20 April 2004
Caspase activation has been frequently viewed as synonymous with apoptotic cell death; however, caspases can also contribute to processes that do not culminate in cell demise. Moreover, inhibition of caspases can have cytoprotective effects.
In a number of different models, caspase inhibition does not maintain cellular viability and instead shifts the morphology of death from apoptosis to nonapoptotic pathways.
cell death inhibition
mitochondrial membrane permeabilization
Kroemer G, Martin SJ. Caspase-independent cell death. Nat Med. 2005 Jul;11(7):725-30. PMID: 16015365