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astrocytes

Tuesday 13 April 2004

Adj. astrocytic

Images

- astrocytes and oligodendrocytes

In addition to being essential supporters of neuronal function, astrocytes are active elements in the brain.

Astrocytes sense and integrate synaptic activity and, depending on intracellular Ca(2+) levels, release gliotransmitters (e.g. glutamate, d-serine and ATP) that have feedback actions on neurons.

Pathology

- astrocytary anomalies
- astrocytary diseases
- astrocytary tumors

References

- Halassa MM, Fellin T, Haydon PG. The tripartite synapse: roles for gliotransmission in health and disease. Trends Mol Med. 2007 Feb;13(2):54-63. PMID: 17207662

- Fellin T, Haydon PG. Do astrocytes contribute to excitation underlying seizures? Trends Mol Med. 2005 Dec;11(12):530-3. PMID: 16290019

- Pekny M, Pekna M. Astrocyte intermediate filaments in CNS pathologies and regeneration. J Pathol. 2004 Nov;204(4):428-37. PMID: 15495269

- Nicoll JA, Weller RO. A new role for astrocytes: beta-amyloid homeostasis and degradation. Trends Mol Med. 2003 Jul;9(7):281-2. PMID: 12900213

- Guenette SY. Astrocytes: a cellular player in Abeta clearance and degradation. Trends Mol Med. 2003 Jul;9(7):279-80. PMID: 12900212