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splenic hamartoma

Thursday 8 April 2004

Associations

- refractory microcytic anemia
- sickle cell anemia
- hereditary spherocytosis
- dyserythropoietic hemolytic anemia

Synopsis

- one and multiple bulging nodules
- nodules from 1.3 to 7 cm, indistinct from the surrounding nonlymphoid splenic (red pulp) parenchyma
- red splenic pulp with variable histiocytic proliferation, focal extramedullary hematopoiesis, lympho-plasmacytosis, fibrosis, and siderotic-calcific deposits
- intranodular small T- and B-cell lymphoid aggregates
- no organized secondary follicles or periarteriolar sheaths

Differential diagnosis

- benign vascular tumors

References

- Abramowsky C, Alvarado C, Wyly JB, Ricketts R. "Hamartoma" of the Spleen (Splenoma) in Children. Pediatr Dev Pathol. 2004 Mar 25. PMID: 15037946