Humpath.com - Human pathology

Home > A. Molecular pathology > Signaling pathways > MAPK signaling pathway

MAPK signaling pathway

Wednesday 11 June 2003

MAPK Pathway; RAS/RAF/MAPK signaling pathway, MAPK signalling pathway, extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway, ERK/MAPK pathway, Ras signaling pathway, RAS-ERK signaling pathway, RAS/RAF/MAP/ERK kinase pathway

Members

ERK BRAF RASs MAPKs

Pathology

- malignant melanoma

  • The MAPK pathway is a key therapeutic target for melanoma as it is activated in most tumors.

- Erdheim-Chester disease

Links

- Animation of the organisation and function of the Ras-Raf-MEK-ERK pathway at Expert Reviews in Molecular Medicine

- kinase.uhnres.utoronto.ca

See also

- RASs: HRAS , KRAS , NRAS

References

- Kim IA, Fernandes AT, Gupta AK, McKenna WG, Bernhard EJ. The influence of Ras pathway signaling on tumor radiosensitivity. Cancer Metastasis Rev. 2004 Aug;23(3-4):227-36. PMID: 15197325

- Downward J. Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer. 2003 Jan;3(1):11-22. PMID: 12509763

- Stork PJ, Schmitt JM. Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation. Trends Cell Biol. 2002 Jun ;12(6):258-66. PMID : 12074885

- Hazzalin CA, Mahadevan LC. MAPK-regulated transcription: a continuously variable gene switch? Nat Rev Mol Cell Biol. 2002 Jan;3(1):30-40. PMID: 11823796

- Madhani HD, Fink GR. The riddle of MAP kinase signaling specificity. Trends Genet. 1998 Apr;14(4):151-5. PMID: 9594663

- Breitkreutz A, Tyers M. MAPK signaling specificity : it takes two to tango. Trends Cell Biol. 2002 Jun ;12(6):254-7. PMID : 12074884

Portfolio