Home > G. Tumoral pathology > congenital fibrosarcoma

congenital fibrosarcoma

Thursday 25 March 2004

Localization

- soft tissues
- digestive congenital fibrosarcoma

  • duodenal congenital fibrosarcoma (#1185470#)
  • jejunal congenital fibrosarcoma (#12776248#)
  • ileal congenital fibrosarcoma
  • colonic congenital fibrosarcoma

Cytogenetics

- translocation t(12;15)(p13;q25) with ETV6/NTRK3 fusion gene
- trisomy 11 (#1524466#)
- trisomy 8
- trisomy 17
- trisomy 20 (#1524466#)

Molecular biology

- ETV6/NTRK3 fusion gene by translocation t(12;15)(p13;q25)

Open references

- ETV6 rearrangements in patients with infantile fibrosarcomas and congenital mesoblastic nephromas by fluorescence in situ hybridization. Adem C, Gisselsson D, Dal Cin P, Nascimento AG. Mod Pathol. 2001 Dec;14(12):1246-51. PMID: #11743047# [Free]

- Congenital-infantile fibrosarcoma. A clinicopathologic study of 10 cases and molecular detection of the ETV6-NTRK3 fusion transcripts using paraffin-embedded tissues. Sheng WQ, Hisaoka M, Okamoto S, Tanaka A, Meis-Kindblom JM, Kindblom LG, Ishida T, Nojima T, Hashimoto H. Am J Clin Pathol. 2001 Mar;115(3):348-55. PMID: #11242790# [Free]

- Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic nephroma in paraffin-embedded tissue: application to challenging pediatric renal stromal tumors. Argani P, Fritsch M, Kadkol SS, Schuster A, Beckwith JB, Perlman EJ. Mod Pathol. 2000 Jan;13(1):29-36. PMID: #10658907# [Free]

- Congenital mesoblastic nephroma t(12;15) is associated with ETV6-NTRK3 gene fusion: cytogenetic and molecular relationship to congenital (infantile) fibrosarcoma. Rubin BP, Chen CJ, Morgan TW, Xiao S, Grier HE, Kozakewich HP, Perez-Atayde AR, Fletcher JA. Am J Pathol. 1998 Nov;153(5):1451-8. PMID: #9811336# [Free]

- ETV6-NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma. Knezevich SR, Garnett MJ, Pysher TJ, Beckwith JB, Grundy PE, Sorensen PH. Cancer Res. 1998 Nov 15;58(22):5046-8. PMID: #9823307# [Free]

References

- Bourgeois JM, Knezevich SR, Mathers JA, Sorensen PH. Molecular detection of the ETV6-NTRK3 gene fusion differentiates congenital fibrosarcoma from other childhood spindle cell tumors. Am J Surg Pathol. 2000 Jul;24(7):937-46. PMID: #10895816#

- Argyle JC, Tomlinson GE, Stewart D, Schneider NR. Ultrastructural, immunocytochemical, and cytogenetic characterization of a large congenital fibrosarcoma. Arch Pathol Lab Med. 1992 Sep;116(9):972-5. PMID: #1524466#

- A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH. Nat Genet. 1998 Feb;18(2):184-7. PMID: #9462753#

Portfolio

  • Herringbone pattern in a congenital fibrosarcoma.
  • Herringbone pattern in a congenital fibrosarcoma.
  • ETV6-NTRK3+ congenital fibrosarcoma
  • ETV6-NTRK3+ congenital fibrosarcoma
  • ETV6-NTRK3+ congenital fibrosarcoma
  • ETV6-NTRK3+ congenital fibrosarcoma
  • Negative desmin in an ETV6-NTRK3+ congenital fibrosarcoma
  • HHF35 actins+ in an ETV6-NTRK3+ congenital fibrosarcoma
  • Smooth muscle actin+ in an ETV6-NTRK3+ congenital fibrosarcoma
  • Congenital fibrosarcoma