Humpath.com - Human pathology

Home > E. Pathology by systems > Respiratory system > Lungs > small cell lung carcinoma

small cell lung carcinoma

Thursday 18 March 2004

SCLC; small-cell lung cancer.

Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis. Over 95% of patients with small-cell lung cancer (SCLC) die within five years of diagnosis.

Images

- Wikimedia: Lung small cell carcinoma - Diff-Quick cytology

Videos

- Small cell lung carcinoma (by Washington Deceit)

@<@object width="425" height="350">@<@param name="movie" value="http://www.youtube.com/v/NjkW97IsBjA">@<@/param>@<@param name="wmode" value="transparent">@<@/param>@<@embed src="http://www.youtube.com/v/NjkW97IsBjA" type="application/x-shockwave-flash" wmode="transparent" width="425" height="350">@<@/embed>@<@/object>

Sequencing

- Evidences for inactivation of TP53 and RB1 have been found. (22941188)
- Recurrent mutations in the CREBBP, EP300 and MLL genes that encode histone modifiers. (22941188)
- Mutations in PTEN, SLIT2 and EPHA7. (22941188)
- Focal amplifications of the FGFR1 tyrosine kinase gene. (22941188)

A study implicates histone modification as a major feature of SCLC. (22941188)

References

- Small Cell Lung Cancer: Can recent advances in biology and molecular biology be translated into improved outcomes? Bunn PA Jr, Minna J, Augustyn A et al. J Thorac Oncol. 2016 Jan 29. pii: S1556-0864(16)00335-X. doi : 10.1016/j.jtho.2016.01.012 PMID: 26829312

- Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Peifer M, Fern├índez-Cuesta L, Sos ML et al. Nat Genet. 2012 Oct;44(10):1104-10. PMID: 22941188

- Hann CL, Rudin CM. Fast, hungry and unstable: finding the Achilles’ heel of small-cell lung cancer. Trends Mol Med. 2007 Apr;13(4):150-7. PMID: 17324626

- Wistuba II, Gazdar AF, Minna JD. Molecular genetics of small cell lung carcinoma. Semin Oncol. 2001 Apr;28(2 Suppl 4):3-13. PMID: 11479891