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juvenile polyp

Thursday 18 March 2004

Juvenile polyps are hamartomatous polyps found primarily in infants and children.

Predisposition

- juvenile polyposis (JP) (MIM.174900) (MADH4 and BMPR1A mutations)
- Cowden syndrome (CS) (MIM.158350) (PTEN mutations)
- Bannayan-Riley-Ruvalcaba syndrome (BRRS) (MIM.153480) (PTEN mutations)
- neurofibromatosis type 1 (NF1) (#15150783#)

NB: Although solitary juvenile polyps are benign lesions, but when present in juvenile polyposis (JP), they may lead to gastrointestinal cancers.

References

- Merg A, Howe JR. Genetic conditions associated with intestinal juvenile polyps. Am J Med Genet C Semin Med Genet. 2004 Aug 15;129(1):44-55. PMID: #15264272#

Portfolio

  • Juvenile polyp. Macroscopy.
  • Juvenile polyp. HE x1.
  • Juvenile polyp. HE 1x.
  • Juvenile polyp. HE 1x.
  • Juvenile polyp. HE 1x.
  • CD3 immunostaining in juvenile polyp
  • CD20 immunostaining in juvenile polyp.
  • Juvenile polyp
  • Rectal juvenile polyp
  • Rectal juvenile polyp
  • Rectal juvenile polyp
  • Rectal juvenile polyp
  • Juvenile polyps in juvenile polyposis
  • Juvenile polyp
  • Juvenile polyp