Thursday 18 March 2004
Juvenile polyps are hamartomatous polyps found primarily in infants and children.
juvenile polyposis (JP) (MIM.174900) (MADH4 and BMPR1A mutations)
Cowden syndrome (CS) (MIM.158350) (PTEN mutations)
Bannayan-Riley-Ruvalcaba syndrome (BRRS) (MIM.153480) (PTEN mutations)
neurofibromatosis type 1 (NF1) (15150783)
NB: Although solitary juvenile polyps are benign lesions, but when present in juvenile polyposis (JP), they may lead to gastrointestinal cancers.
Merg A, Howe JR. Genetic conditions associated with intestinal juvenile polyps. Am J Med Genet C Semin Med Genet. 2004 Aug 15;129(1):44-55. PMID: 15264272