Monday 15 March 2004
uterine leiomyomata, uterine fibroids
Uterine leiomyoma occurs in about 20-30% of women over the age of 30, and is the most frequent benign tumor in gynecology.
FH-associated uterine leiomyoma
Cytogenetic analysis of uterine leiomyomata (UL) shows that about 40% of these benign tumors have simple, clonal chromosomal rearrangements.
- often associated with other aberrations, particularly loss of chromosomes 19 (19-) and/or 22 (22-)
- cellular UL
- hypercellularity and nuclear atypia
- t(10;17) disrupts the histone acetyltransferase MORF (10q22) (monocytic leukemia zinc finger protein-related factor or MYST4). (15313893)
LOH and deletions
12q14 LOH (HMGA2)
15q26 LOH (15605361)
cellular uterine leiomyoma
Wang T, Zhang X, Obijuru L, Laser J, Aris V, Lee P, Mittal K, Soteropoulos P, Wei JJ. A micro-RNA signature associated with race, tumor size, and target gene activity in human uterine leiomyomas. Genes Chromosomes Cancer. 2007 Apr;46(4):336-47. PMID: 17243163
Quade BJ, Wang TY, Sornberger K, Dal Cin P, Mutter GL, Morton CC. Molecular pathogenesis of uterine smooth muscle tumors from transcriptional profiling. Genes Chromosomes Cancer. 2004 Jun;40(2):97-108. PMID: 15101043
Dal Cin P, Morton CC. 1q42 approximately q44 is rarely cytogenetically involved in sporadic uterine leiomyomata. Cancer Genet Cytogenet. 2002 Oct 1;138(1):92-3. PMID: 12419594