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uterine leiomyoma

Monday 15 March 2004

Uterine leiomyoma occurs in about 20-30% of women over the age of 30, and is the most frequent benign tumor in gynecology.

Cytogenetics

Cytogenetic analysis of uterine leiomyomata (UL) shows that about 40% of these benign tumors have simple, clonal chromosomal rearrangements.

- near-diploid karyotypes with del(1)(p11p36) (16320247)

  • often associated with other aberrations, particularly loss of chromosomes 19 (19-) and/or 22 (22-)
  • cellular UL
  • hypercellularity and nuclear atypia

- 1q42 rearrangement (FH, fumarate hydratase) (15334541, 12419594)

- 10q22

  • t(10;17) disrupts the histone acetyltransferase MORF (10q22) (monocytic leukemia zinc finger protein-related factor or MYST4). (15313893)

LOH and deletions

- del(1)(p11p36) (16320247)

- 1q42 LOH and 1q42 deletions (FH, fumarate hydratase) (15334541, 12419594)

- 7p15 LOH (15605361)

- 7p22

- 7q LOH (9%) (10484989, 9869453)

- 12q14 LOH (HMGA2)
- 15q26 LOH (15605361)

Molecular biology

- allelotyping: 9869453
- transcriptional profiling: 15101043

Variants

- cellular uterine leiomyoma

References

- Wang T, Zhang X, Obijuru L, Laser J, Aris V, Lee P, Mittal K, Soteropoulos P, Wei JJ. A micro-RNA signature associated with race, tumor size, and target gene activity in human uterine leiomyomas. Genes Chromosomes Cancer. 2007 Apr;46(4):336-47. PMID: 17243163

- Quade BJ, Wang TY, Sornberger K, Dal Cin P, Mutter GL, Morton CC. Molecular pathogenesis of uterine smooth muscle tumors from transcriptional profiling. Genes Chromosomes Cancer. 2004 Jun;40(2):97-108. PMID: 15101043

- Dal Cin P, Morton CC. 1q42 approximately q44 is rarely cytogenetically involved in sporadic uterine leiomyomata. Cancer Genet Cytogenet. 2002 Oct 1;138(1):92-3. PMID: 12419594

Portfolio

  • Uterine leiomyoma. Macroscopy.
  • Uterine leiomyoma under the mucosa
  • Uterine leiomyoma under the mucosa - tumor cut
  • Multiple uterine leiomyomas
  • Uterine leiomyoma
  • Uterine leiomyomas.
  • Submucosal uterine leiomyoma
  • Parietal uterine leiomyoma
  • Parietal uterine leiomyoma
  • Parietal uterine leiomyoma
  • Subserosal uterine leiomyoma
  • Subserosal uterine leiomyoma
  • Subserosal uterine leiomyoma
  • Myxoid degeneration of an uterine leiomyoma
  • Necrobiotic subserosal uterine leiomyoma
  • Necrobiotic subserosal uterine leiomyoma
  • Necrobiotic subserosal uterine leiomyoma
  • Necrobiotic subserosal uterine leiomyoma
  • Necrotic subserosal uterine leiomyoma
  • Necrotic subserosal uterine leiomyoma