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Granulomas

Tuesday 10 June 2003

Digital slides

- UI:872 - Foreign body granuloma (Foreign body reaction)

Definition: A granuloma is a solid grouping of inflammatory cells coming together in a lump or solid structure resulting from injury or inflammation or infection. Thus, granulomas are loosely defined as collections of inflammatory cells.

Classification

- epithelioid granuloma

  • Epithelioid granulomas are well-demarcated and are composed of variable numbers of lymphocytes, occasional plasma cells, and prominent numbers of activated macrophages which have round to indented clear nuclei and abundant eosinophilic cytoplasm (epithelioid cells).

- tuberculoid granuloma

  • Multinucleated giant cells are sometimes seen.

- inflammatory granuloma

  • Inflammatory granulomas are usually smaller than the epithelioid type and are composed of a mixed inflammatory infiltrate consisting of lymphocytes, macrophages, and occasional plasma cells, neutrophils and eosinophils.
  • These granulomas may or may not be poorly demarcated. Although occasional multinucleated giant cells can be seen, they are much less frequent than in the epithelioid granulomas.
  • A combination of both epithelioid and inflammatory granulomas may be seen within the same biopsy specimen.

- necrotizing granuloma
- eosinophilic granuloma
- palisading granuloma
- giant cell reparative granuloma
- fibrin-ring granuloma
- angiocentric granuloma
- cholesterol granuloma
- foreign body granuloma (foreign body reaction)

  • injection granuloma
  • cholesterol granuloma

Links

- Atlas of Granulomatous Diseases by Yale Rosen, M.D.

See also

- granulation tissue
- granulomatoses

  • tuberculoid granulomatosis
  • necrotizing granulomatosis

Portfolio

  • Suppurative epithelioid granuloma in a chalazion
  • Suppurative epithelioid granuloma in a chalazion
  • Suppurative epithelioid granuloma in familial granulomatous disease (...)
  • Suppurative epithelioid granuloma in familial granulomatous disease (...)