Tuesday 10 June 2003
Definition: A granuloma is a solid grouping of inflammatory cells coming together in a lump or solid structure resulting from injury or inflammation or infection. Thus, granulomas are loosely defined as collections of inflammatory cells.
- Epithelioid granulomas are well-demarcated and are composed of variable numbers of lymphocytes, occasional plasma cells, and prominent numbers of activated macrophages which have round to indented clear nuclei and abundant eosinophilic cytoplasm (epithelioid cells).
- epithelioid cells and Langhans multinucleated giant cells
- Inflammatory granulomas are usually smaller than the epithelioid type and are composed of a mixed inflammatory infiltrate consisting of lymphocytes, macrophages, and occasional plasma cells, neutrophils and eosinophils.
- These granulomas may or may not be poorly demarcated. Although occasional multinucleated giant cells can be seen, they are much less frequent than in the epithelioid granulomas.
- A combination of both epithelioid and inflammatory granulomas may be seen within the same biopsy specimen.
giant cell reparative granuloma
foreign body granuloma (foreign body reaction)
- injection granuloma
- cholesterol granuloma
Atlas of Granulomatous Diseases by Yale Rosen, M.D.
- tuberculoid granulomatosis
- necrotizing granulomatosis