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talins

Sunday 14 March 2004

Members

talin-1 talin-2 talin-3

Functions

Talins link vinculin (MIM.193065) to the integrins, and, thus, the cytoskeleton and actin to extracellular matrix (ECM) receptors.

It has a mass of 270 kD and shares 23% N-terminal identity with ezrin (MIM.123900), which has similar functions.

References

- Cram EJ, Schwarzbauer JE. The talin wags the dog: new insights into integrin activation. Trends Cell Biol. 2004 Feb;14(2):55-7. PMID: 15106607