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bone marrow allograft

Friday 12 March 2004

Complications

- graft-versus-host disease (GVHD)

  • acute GVHD
  • chronic GVHD

- opportunistic infections
- drug toxicity

- BMA-associated vasculopathies

  • veno-occlusive disease (BMA-VOD)
  • bone marrow allograft-associated thrombotic microangiopathy (BMA-TMA)
  • hemolytic uremic syndrome (BMA-HUS)
  • thrombotic thrombocytopenic purpura (BMA-TTP)
  • post-allograft small muscular arteries vasculopathy (BMA-SMAV) (#10414490#)

- venoocclusive disease of the liver

- pulmonary lesions

  • bronchiolitis obliterans
  • constrictive bronchiolitis
  • organizing pneumonia (BOOP)
  • alveolar proteinosis
  • diffuse alveolar damage
  • diffuse alveolar hemorrhages (DAH) (#7581082#)

- digestive lesons

  • gastrointestinal bleeding
  • digestive GVHD (intestinal graft versus host disease)
  • pneumatosis intestinalis
  • digestive perforation
  • pneumoperitoneum
  • necrotizing enteritis
  • cholecystitis
  • small bowel obstruction
  • appendicitis

References

- Mullighan CG, Bardy PG. New Directions in the Genomics of Allogeneic Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2007 Feb;13(2):127-144. PMID: #17241919#

- Jones AD, Maziarz R, Gilster J, Domreis J, Deveney CW, Sheppard BC. Surgical complications of bone marrow transplantation. Am J Surg. 2003 May;185(5):481-4. PMID: #12727571#