Wednesday 10 March 2004
Digital cases (Digital slides)
Definition: Teratomas are the most common germ cell tumor (GCT) of the ovary and include several types with a range of clinical behavior. As in testicular teratomas, they may be benign, malignant or a component of a mixed GCT.
In the testis, data support separate pathogeneses for prepubertal and postpubertal teratomas, with derivation of the former from a nontransformed germ cell and the latter from differentiation of a nonteratomatous, malignant GCT.
The absence of cytogenetic abnormalities (including isochromosome 12p (i(12p)) in mature ovarian teratomas suggests that they may be analogous to prepubertal testicular teratomas.
ovarian mature teratoma (ovarian mature cystic teratoma)
- ovarian multitissular mature teratoma
- ovarian dermoid cysts
ovarian immature teratoma
ovarian germ cell tumors (OGCTs)
- ovarian mixed germ cell tumors (OMGCTs)
Analysis of ovarian teratomas for isochromosome 12p: evidence supporting a dual histogenetic pathway for teratomatous elements. Poulos C, Cheng L, Zhang S, Gersell DJ, Ulbright TM. Mod Pathol. 2006 Jun;19(6):766-71. PMID: 16547466 (Free)
Evidence of parthenogenetic origin of ovarian teratoma: case report. Oliveira FG, Dozortsev D, Diamond MP, Fracasso A, Abdelmassih S, Abdelmassih V, Gonçalves SP, Abdelmassih R, Nagy ZP. Hum Reprod. 2004 Aug;19(8):1867-70. PMID: 15192066