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Leukemias

Monday 9 June 2003

Digital slides

- Acute leukemia after essential thrombocytosis: Descartes #9963 (ICSF)

Digital cases

- Case HPC:277 (Acute leukemia after essential thrombocytosis)

Types

- acute leukemias
- chronic leukemias

Classification

- lymphoid leukemias

  • acute lymphocytic leukemias (ALL)
    • T-cell acute lymphocytic leukemia
    • mature B-cell leukemias
    • T/NK cell-leukemias
  • T-cell large granular lymphocyte leukemia
  • T-cell prolymphocytic leukemia

- myeloid leukemias

- biphenotypic acute leukemia (BAL)
- systemic mast cell disease (SMCD)

Oncogenetics

Human leukemia cells containing characteristic chromosomal translocations and inversions have been instrumental in identifying fusion genes implicated in the pathogenesis of the corresponding leukemia.

Although chimeric fusion genes usually provide early and essential steps in the development of leukemia, they are not in themselves sufficient, requiring additional genetic events. The nature of these secondary, cooperating genetic events is not known.

See also

- congenital leukemias (neonatal leukemias)
- infant leukaemias

References

- Gilliland DG, Jordan CT, Felix CA. The molecular basis of leukemia. Hematology (Am Soc Hematol Educ Program). 2004;:80-97. PMID: 15561678

- Greaves MF, Wiemels J. Origins of chromosome translocations in childhood leukaemia. Nat Rev Cancer. 2003 Sep;3(9):639-49. PMID: 12951583

- Staudt LM. Molecular diagnosis of the hematologic cancers.
N Engl J Med. 2003 May 1;348(18):1777-85. PMID: 12724484

- Bohlander SK. Fusion genes in leukemia: an emerging network. Cytogenet Cell Genet. 2000;91(1-4):52-6. PMID: 11173830

- Rowley JD. The critical role of chromosome translocations in human leukemias. Annu Rev Genet 1998;32:495-519. PMID: 9928489


- Leukemias at AGCOH (Atlas of Genetics and Cytogenetics in Oncology and Haematology)