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membranous glomerulonephritis

Monday 8 March 2004, by JA

Synopsis

- thickening of glomerular basal membranes
- subepithelial immune deposits
- no increase in mesangial cell numbers
- IF:
diffuse granular deposits along the GBM
positivity for lgG and often C3 (sometimes low level of staining for IgM or IgA).

Ultrastructure

- early subepithelial deposits

References

- M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. Beck LH Jr, Bonegio RG, Lambeau G, Beck DM, Powell DW, Cummins TD, Klein JB, Salant DJ. N Engl J Med. 2009 Jul 2;361(1):11-21. PMID: #19571279#

- Molecular pathomechanisms of membranous nephropathy: from Heymann nephritis to alloimmunization. Ronco P, Debiec H. J Am Soc Nephrol. 2005 May;16(5):1205-13. PMID: #15800120#

Portfolio

  • Membranous glomerulonephritis (Masson's trichrome stain)
  • Membranous glomerulonephritis (silver stain)