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motor proteins

Sunday 7 March 2004

Proteins participating in many different intracellular transport systems.

Members

- kinesins (KIFs)
- dyneins
- myosins: MYOs, MYHs, MYLs

Pathology (diseases linked to motor proteins)

- kinesin KIF1B: mutations in the Charcot-Marie-Tooth disease type 2A
- dyneins: mutations in the immotile cilia syndrome
- unconventional myosins: hereditary human hearing impairment

See also

- microtubule-dependent protein motors

Animations

- Axonal transport: A movie from J Cell Biol

References

- Hirokawa N, Takemura R. Molecular motors and mechanisms of directional transport in neurons. Nat Rev Neurosci. 2005 Mar;6(3):201-14. PMID: 15711600

- Mallik R, Gross SP. Molecular motors: strategies to get along. Curr Biol. 2004 Nov 23;14(22):R971-82. PMID: 15556858

- Holzbaur EL. Motor neurons rely on motor proteins. Trends Cell Biol. 2004 May;14(5):233-40. PMID: 15130579

- Gunawardena S, Goldstein LS. Cargo-carrying motor vehicles on the neuronal highway: transport pathways and neurodegenerative disease. J Neurobiol. 2004 Feb 5;58(2):258-71. PMID: 14704957

- Hirokawa N, Takemura R. Biochemical and molecular characterization of diseases linked to motor proteins. Trends Biochem Sci. 2003 Oct;28(10):558-65. PMID: 14559185

- Kamal A, Goldstein LS. Principles of cargo attachment to cytoplasmic motor proteins. Curr Opin Cell Biol. 2002 Feb;14(1):63-8. PMID: 11792546

- Goldstein LS. Molecular motors: from one motor many tails to one motor many tales. Trends Cell Biol. 2001 Dec;11(12):477-82. PMID: 11719052

- Terada S, Hirokawa N. Moving on to the cargo problem of microtubule-dependent motors in neurons. Curr Opin Neurobiol. 2000 Oct;10(5):566-73. PMID: 11084318


- Molecular motors ->http://wilkes1.wilkes.edu/~terzaghi/BIO-226/lectures/25.html Bio 226 Lecture 25: February 25, 2004