Monday 9 June 2003
Clathrin is the main structural component of the lattice covering the cytoplasmic face of the coated pits and coated vesicles in which specific macromolecules are entrapped in the process of receptor-mediated endocytosis.
Clathrin is a large, soluble protein composed of heavy chains (CLTC) (molecular size, about 192 kD) and light chains CLTA and CLTB (molecular size, about 32-38 kD).
fusion gene in inflammatory myofibroblastic tumors (IMF)
Brooksbank C. Endocytosis. Tent pegs for clathrin. Nat Rev Mol Cell Biol. 2001 Mar;2(3):166. PMID: 11265244
Dell’Angelica EC. Clathrin-binding proteins: got a motif? Join the network. Trends Cell Biol. 2001 Aug;11(8):315-8. PMID: 11489622