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atypical urothelial cells

Friday 15 April 2022

AUC

4 cytomorphologic features in predicting HGUC :
- nuclear cytoplasmic ratio
- hyperchromasia
- irregular nuclear membrane
- coarse chromatin

Criteria for diagnosing atypical urothelial cells include one major and one minor criterion :

- The major or required criterion is the presence of non-superficial and non-degenerated urothelial cells with an increased nuclear cytoplasmic (N/C) ratio (>0.5).
- The minor criteria, of which only one is required, include:

  • (1) mild nuclear hyperchromasia
  • (2) irregular nuclear membranes (chromatinic rim or nuclear contour)
  • (3) irregular, coarse, clumped chromatin.

Open references

- https://www.karger.com/Article/FullText/446270