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invasive mucinous adenocarcinoma

Tuesday 5 October 2021


Definition: Distinct variant of lung adenocarcinoma with a goblet or columnar morphology and abundant intracytoplasmic mucin.

Differential diagnosis

- metastatic colorectal adenocarcinoma:
Endoscopic and radiologic examination critical
Usually multifocal
Tend to be more solid and dense
Proliferation of neoplastic columnar cells with abundant intracytoplasmic mucin
CDX2 and CK20 positive

- pulmonary colloid adenocarcinoma (Hum Pathol 2015;46:836):
Marked mucin pool replacing normal parenchyma
Neoplastic epithelium floating in the mucin
Fragments of displaced alveolar walls
Minimal nuclear atypia
Fibrotic encapsulation in minor cases (formerly called cystadenocarcinoma)