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salivary gland tumors

Monday 1 March 2004

salivary tumors; salivary gland neoplasms

Images

- Webpathology: http://www.webpathology.com/category.asp?category=19

Appearance

- salivary gland tumors with cribroform pattern

Epidemiology

Salivary gland neoplasms comprise less than 2% of all tumors in humans and 3% of all head and neck tumors. 80% of them are benign and only 20% are malignant.

Salivary gland neoplasms are relatively uncommon, with an overall incidence of 2.5 to 3 cases per 100,000 persons in the Western world.

The majority of these lesions (approximately 70%–80%) originate in the parotid gland.

Malignant salivary gland tumors are considerably less common; they account for approximately 3% to 5% of all head and neck cancers and have a tendency to present in the sixth or seventh decades of life.

Classification WHO 52017 - Tumours of the salivary glands

- malignant epithelial tumors : salivary carcinomas

- salivary epithelial benign tumors

  • salivary cystadenoma

- NON-WHO 2017 entities

- salivary mesenchymal tumors

- salivary lymphomas
- salivary metastatic tumors

Images

- salivary gland epithelial tumors

- salivary epithelial benign tumors

  • salivary cystadenoma
  • salivary sebaceous adenoma
  • siladenoma
  • salivary lymphadenoma
  • salivary ductal papillomas
    • salivary intraductal papilloma
    • salivary inverted ductal papilloma
    • siladenoma papilliferum

- salivary epithelial malignant tumors

  • salivary duct carcinoma
  • salivary myoepithelial carcinoma
  • salivary small cell undifferenciated carcinoma (neuroendocrine features) (14763575)
  • salivary gland anlage tumor (SGAT)

- salivary mesenchymal tumors

  • osteoclast-type giant cell neoplasm of salivary gland
  • salivary hemangioma
  • salivary lipoma
  • salivary lymphangioma
  • salivary malignant schwannoma
  • salivary hemangiopericytoma
  • salivary malignat fibrous histiocytoma

- salivary lymphomas
- salivary metastatic tumors

Immunochemistry

- Review and Updates of Immunohistochemistry in Selected Salivary Gland and Head and Neck Tumors. 2016

Variants

- pediatric salivary tumors

Diagnosis

- epithelial tumors

  • malignant epithelial tumors
    • acinic cell carcinoma
    • mucoepidermoidcarcinoma
    • adenoid cystic carcinoma
    • polymorphous low-grade adenocarcinoma
    • epithelial-myoepithelial carcinoma
    • clear cell carcinoma, NOS
    • basal cell adenocarcinoma
    • malignant sebaceous tumors (sebaceous carcinoma , sebaceous lymphadenocarcinoma )
    • cystadenocarcinoma
    • low-grade cribriform cystadenocarcinoma
    • mucinous adenocarcinoma
    • oncocytic carcinoma
    • salivary duct carcinoma
    • adenocarcinoma , NOS
    • myoepithelial carcinoma
    • carcinoma ex pleomorphic adenoma
    • carcinosarcoma
    • squamous cell carcinoma
    • small cell carcinoma
    • large cell carcinoma
    • lymphoepithelial carcinoma
    • sialoblastoma

- mesenchymal tumors

- mixed tumors

  • pleomorphic adenoma
  • metastasizing pleomorphic adenoma

- secondary tumors

Fusion genes in salivary tumors

- PLAG1 rearrangements in pleomorphic adenoma

- MAML2-TORC1 in MEC, WAT, clear cell hidradenoma

- MYB-NFIB in ACC, dermal cylindroma

- ATF1-EWSR1 in clear cell carcinoma

Links

- Atlas of Salivary Gland Tumors by Faramarz Naeim, MD (UCLA)

See also

- salivary glands
- salivary gland pathology
- salivary gland anomalies

- pediatric epithelial salivary gland tumors

References

- https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb9/bb9-chap5.pdf

- Pediatric epithelial salivary gland tumors: Spectrum of histologies and cytogenetics at a Children’s Hospital. Craver RD, Fonseca P, Carr R. Pediatr Dev Pathol. 2010 Jan 7. PMID: 20055685

Portfolio

  • Salivary gland anlage tumor
  • Salivary gland anlage tumor