Home > D. Systemic pathology > Infectious diseases > HHV-6

HHV-6

Wednesday 11 February 2004

Herpesvirus 6 (HHV-6) is a ubiquitous virus known to cause febrile syndromes and exanthema subitum in children. Less commonly, and particularly in organ transplant recipients, it may result in hepatitis, bone marrow suppression, interstitial pneunonitis, and meningoencephalitis.

Pathology

- HHV6-associated hepatitis
- HHV6-associated myocarditis (#11577130#)
- HHV6-associated bone marrow suppression
- HHV6-associated interstitial pneunonitis
- HHV6-associated meningoencephalitis
- HHV6-associated gastroduodenitis (immunosuppressed individuals)
- HHV6-associated pancreatitis (immunosuppressed individuals)

Synopsis

- cytopathic effect

  • multinucleate giant cells
  • gastric, duodenal, and bile ductular epithelium showing a multinucleate giant cell transformation similar to the caused by the virus in human T-lymphocytes infected in vitro

- electron microscopy

  • herpes particles with a thick tegument layer in the duodenum
  • multinucleate giant cells and enveloped virions with a prominent tegument

- polymerase chain reaction

  • amplification of HHV6 sequences

- Serology

  • anti HHV-6 antibodies

Predisposition

- immunosuppression

. Thus, HHV-6 variant A can cause gastroduodenitis and pancreatitis in . Multinucleate giant cells and enveloped virions with a prominent tegument can be used as morphologic criteria to raise the possibility of HHV-6 infection in human biopsy tissue.

Pathology

- HHV6-associated hepatitis

References

- Aita K, Jin Y, Irie H, Takahashi I, Kobori K, Nakasato Y, Kodama H, Yanagawa Y, Yoshikawa T, Shiga J. Are there histopathologic characteristics particular to fulminant hepatic failure caused by human herpesvirus-6 infection? A case report and discussion. Hum Pathol. 2001 Aug;32(8):887-9. PMID: #11521236#

- Tao Q, Ambinder RF. Lack of Kaposi’s sarcoma-associated virus (KSHV) and detection of human herpes virus 6 and 7 by PCR in African Burkitt’s lymphoma from HIV-negative patients. Hum Pathol. 1999 Oct;30(10):1269-70. PMID: #10534180#

- Hoang MP, Dawson DB, Rogers ZR, Scheuermann RH, Rogers BB. Polymerase chain reaction amplification of archival material for Epstein-Barr virus, cytomegalovirus, human herpesvirus 6, and parvovirus B19 in children with bone marrow hemophagocytosis. Hum Pathol. 1998 Oct;29(10):1074-7. PMID: #9781644#

- Carbone A, Dolcetti R, Gloghini A, Maestro R, Vaccher E, di Luca D, Tirelli U, Boiocchi M. Immunophenotypic and molecular analyses of acquired immune deficiency syndrome-related and Epstein-Barr virus-associated lymphomas: a comparative study. Hum Pathol. 1996 Feb;27(2):133-46. PMID: #8617454#

- Hammerling JA, Lambrecht RS, Kehl KS, Carrigan DR. Prevalence of human herpesvirus 6 in lung tissue from children with pneumonitis. J Clin Pathol. 1996 Oct;49(10):802-4. PMID: #8943744#

- Kempf W, Adams V, Pfaltz M, Briner J, Schmid M, Moos R, Hassam S. Human herpesvirus type 6 and cytomegalovirus in AIDS-associated Kaposi’s sarcoma: no evidence for an etiological association. Hum Pathol. 1995 Aug;26(8):914-9. PMID: #7635454#

- Vinters HV, Wang R, Wiley CA. Herpesviruses in chronic encephalitis associated with intractable childhood epilepsy. Hum Pathol. 1993 Aug;24(8):871-9. PMID: #8397159#