Home > G. Tumoral pathology > giant cell angioblastoma

giant cell angioblastoma

Wednesday 11 February 2004

Locally aggressive soft-tissue tumor.

Microscopy

- solid, nodular, and plexiform proliferation of oval-to-spindle cells
- frequent striking, concentric aggregation around small vascular channels
- nodular cell clusters resembling inflammatory granulomas
- giant, multinucleated cells.

Histogenesis

- cellular aggregates were interpreted as distorted attempts at formation of vessels.

Immunochemistry

- stromal cells positive for factor XIIIa
- stromal cells positive for histocompatability antigen (HLA)-DR

References

- Vargas SO, Perez-Atayde AR, Gonzalez-Crussi F, Kozakewich HP. Giant cell angioblastoma: three additional occurrences of a distinct pathologic entity. Am J Surg Pathol. 2001 Feb;25(2):185-96. PMID: #11176067#

- Gonzalez-Crussi F, Chou P, Crawford SE. Congenital, infiltrating giant-cell angioblastoma. A new entity? Am J Surg Pathol. 1991 Feb;15(2):175-83. PMID: #1989466#