giant cell angioblastoma
Wednesday 11 February 2004
Locally aggressive soft-tissue tumor.
solid, nodular, and plexiform proliferation of oval-to-spindle cells
frequent striking, concentric aggregation around small vascular channels
nodular cell clusters resembling inflammatory granulomas
giant, multinucleated cells.
cellular aggregates were interpreted as distorted attempts at formation of vessels.
stromal cells positive for factor XIIIa
stromal cells positive for histocompatability antigen (HLA)-DR
Vargas SO, Perez-Atayde AR, Gonzalez-Crussi F, Kozakewich HP. Giant cell angioblastoma: three additional occurrences of a distinct pathologic entity. Am J Surg Pathol. 2001 Feb;25(2):185-96. PMID: 11176067
Gonzalez-Crussi F, Chou P, Crawford SE. Congenital, infiltrating giant-cell angioblastoma. A new entity? Am J Surg Pathol. 1991 Feb;15(2):175-83. PMID: 1989466