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oral squamous cell papilloma

Friday 13 December 2019

oral squamous papilloma; oral malpighian cell papilloma

http://www.pathologyoutlines.com/topic/oralcavitysquamouspapilloma.html

Definition : Oral squamous cell papilloma is a common intraoral benign epithelial neoplasm. 50% are associated with human papillomavirus (HPV 6 and 11). Others are probably reactive epithelial hyperplasia

Synopsis :
- white-pink cauliflower-like surface projections
- 75% are less than 1 cm
- fibrovascular cores surrounded by benign squamous epithelium
- hyperkeratosis in 82%, parakeratosis in 72%
- variable hyperplasia of basilar cell layer , parabasilar cell layer, prickle cell cell layer or granular cell layer , individual cell keratinization and abnormal mitotic figures
- Often no koilocytotic changes ;
- no downward pushing growth into lamina propria
- possible epithelial dysplasia: significant cytologic atypia and maturation anomalies

Sites: posterior hard palate, soft palate and uvula (34%), dorsum and lateral tongue borders (24%), gingiva (12%), lower lip (12%) and buccal mucosa (6%)

Differential diagnosis :

- multiple lesions

  • focal dermal hypoplasia ( Goltz-Gorlin syndrome )
  • focal epithelial hyperplasia ( Heck disease )
  • inflammatory papillary hyperplasia
  • juvenile papillomatosis
  • papillary appearing lymphoid hyperplasia of tonsils

- solitary lesions

See also

- oral anomalies
- squamous cell papilloma
- papillomatoses / papillomatosis