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multicentric reticulohistiocytosis

Friday 6 February 2004

Multicentric reticulohistiocytosis is a rare disorder with proliferating histiocytes that develop into multinucleated giant cells with "ground-glass" cytoplasm. The disease presents with a rapidly destructive, sometimes permanently debilitating, polyarthritis and a papulonodular eruption, generally of the face and hands.


- skin
- articulations


- Bogle MA, Tschen JA, Sairam S, McNearney T, Orsak G, Knox JM. Multicentric reticulohistiocytosis with pulmonary involvement. J Am Acad Dermatol. 2003 Dec;49(6):1125-7. PMID: 14639398

- Salisbury JR, Hall PA, Williams HC, Mangi MH, Mufti GJ. Multicentric reticulohistiocytosis. Detailed immunophenotyping confirms macrophage origin. Am J Surg Pathol. 1990 Jul;14(7):687-93. PMID: 2192569