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glutamine synthetase

Thursday 26 September 2019

WKP PO

Definition : Glutamine synthetase (GS) (EC 6.3.1.2) is an enzyme that plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine.

Glutamine Synthetase uses ammonia produced by nitrate reduction, amino acid degradation, and photorespiration. The amide group of glutamate is a nitrogen source for the synthesis of glutamine pathway metabolites.

HSP70, GPC3 and GS expressions could be useful biomarkers for increasing the specificity and sensitivity of HCC diagnosis to acceptable level.

Open references

- Diagnostic Value of Glypican3, Heat Shock Protein 70 and Glutamine Synthetase in Hepatocellular Carcinoma Arising in Cirrhotic and Non-Cirrhotic Livers. Uthamalingam P, Das A, Behra A, Kalra N, Chawla Y. J Clin Exp Hepatol. 2018 Jun;8(2):173-180. doi : 10.1016/j.jceh.2017.09.005 PMID: 29892181

- Concomitant use of heat-shock protein 70, glutamine synthetase and glypican-3 is useful in diagnosis of HBV-related hepatocellular carcinoma with higher specificity and sensitivity. Moudi B, Heidari Z, Mahmoudzadeh-Sagheb H, Alavian SM, Lankarani KB, Farrokh P, Randel Nyengaard J. Eur J Histochem. 2018 Jan 29;62(1):2859. doi : 10.4081/ejh.2018.2859 PMID: 29569872