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dermatofibroma with pleomorphic cells

Tuesday 6 November 2018

dermatofibroma with monster cells

Definition : dermatofibroma with monster cells.

Histologic examination :

- characteristic findings of a dermatofibroma, including :

  • rete ridge flattening and bridging;
  • a stroma containing scattered, large, round, eosinophilic collagen bundles;
  • a polymorphous dermal infiltrate of spindle and xanthomatous cells with scattered siderophages.

- Some xanthomatous cells demonstrated features consistent with monster cells, including huge bizarre nuclei and one or more nucleoli.
- Immunohistochemical staining for factor XIIIa is positive.

See also

- Giant dermatofibroma with monster cells. Goodman WT, Bang RH, Padilla RS. Am J Dermatopathol. 2002 Feb;24(1):36-8. PMID: 11803279