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lichen myxedematosus

Monday 17 September 2018

Definition : Scleromyxedema or lichen myxedematosus is a rare papular mucinosis of chronic and progressive course and unknown etiology. It is commonly associated with monoclonal gammopathy and may show extracutaneous manifestations, affecting the heart, lung, kidney, and nerves.

The diagnosis is based on four criteria: generalized papular and sclerodermoid lesions; mucin deposition, fibroblast proliferation, and fibrosis in the histopathology; monoclonal gammopathy; and no thyroid disorders.

Open references

- Lichen Myxedematosus: Strict Classification and Diagnostic Criteria are Still Lacking. Nofal A, Alakad R, Amer H, Nofal E. Indian J Dermatol. 2016 Jan-Feb;61(1):92-3. doi : 10.4103/0019-5154.174040 PMID: 2695510 Free