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sclerozing cutaneous diseases

Monday 17 September 2018

sclerosing skin diseases

Definition: Sclerosing skin diseases represent a large number of distinct disease entities, which include systemic sclerosis , localized scleroderma , and scleredema adultorum.

These pathologies have a common clinical appearance and share histological features. However, the specific interplay between cytokines and growth factors, which activate different mesenchymal cell populations and production of different extracellular matrix components, determines the biomechanical properties of the skin and the clinical features of each disease.

Open references

- Pathophysiological Mechanisms in Sclerosing Skin Diseases. Eckes B, Wang F, Moinzadeh P, Hunzelmann N, Krieg T. Front Med (Lausanne). 2017 Aug 18;4:120. doi : 10.3389/fmed.2017.00120 PMID: 28868289 Free