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MMR-deficient colorectal carcinoma

Friday 7 September 2018

Mismatch Repair Deficient Colorectal Carcinomas.

Mismatch repair-deficient tumors frequently show high-grade histologic features, yet the World Health Organization classifies them as low grade to reflect their favorable prognosis compared with mismatch repair-proficient cancers.

Intestinal-type colorectal adenocarcinomas are graded based on extent of glandular differentiation, although mucinous, signet-ring cell, and solid cancers are, by convention, classified as high grade.

Paywall references

- Tumor Grade is Prognostically Relevant Among Mismatch Repair Deficient Colorectal Carcinomas. Johncilla M, Chen Z, Sweeney J, Yantiss RK. Am J Surg Pathol. 2018 Aug 31. doi : 10.1097/PAS.0000000000001145 PMID: 30179899