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nasal Wegener granulomatosis

Wednesday 7 January 2004

Synopsis

- vascular lesions

  • microabscess in the vascular walls in 82%
  • leukocytoclastic capillaritis in 73%
  • fibrinoid necrosis of blood vessels in 45%
  • eukocytoclastic endovasculitis in 27%, and
  • palisading granuloma in vascular wall in 9% of cases

- extravascular lesions

  • palisading granuloma in all cases
  • microabscess in 91%
  • diffuse granulomatous tissues in 82%
  • Palisading microgranuloma (82%) was more frequent than palisading macrogranuloma (45%)

References

- Matsubara O, Yoshimura N, Doi Y, Tamura A, Mark EJ. Nasal biopsy in the early diagnosis of Wegener’s (pathergic) granulomatosis. Significance of palisading granuloma and leukocytoclastic vasculitis. Virchows Arch. 1996 Apr;428(1):13-9. PMID: #8646364#