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MEIS1

Thursday 6 September 2018

WKP

Definition : Homeobox protein Meis1 is a protein that in humans is encoded by the MEIS1 gene.

Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE (’three amino acid loop extension’) family of homeodomain-containing proteins.

Pathology

- Novel MEIS1-NCOA2 gene fusions define a distinct primitive spindle cell sarcoma of the kidney. (30179902)