Humpath.com - Human pathology

Home > E. Pathology by systems > Reproductive system > Female genital system > Vulva > differentiated vulvar intraepithelial neoplasia

differentiated vulvar intraepithelial neoplasia

Thursday 19 April 2018

uVIN; usual type VIN

WKP PO

Definition : Vulvar intraepithelial neoplasia (VIN) is "usual type" or "classic type", related to human papillomavirus (HPV) infection and affecting relatively young women.

- The usual type includes warty type, basaloid type and mixed (warty and basaloid) type.
- The usual type is HPV associated - it is positive for p16, negative or has low indices for p53, and MIB-1 is strongly positive above the basal layer.
- VIN, usual type (including the sub-categories warty type and basaloid type) are associated with HPV.
- They are HPV and p16 positive, negative for p53, and MIB-1 is strongly positive above the basal layer.
- Usual VIN (warty and basaloid types): Premenopausal, HPV positive, p16 positive, low / negative p53, MIB-1 suprabasal.

See also

- vulvar intraepithelial neoplasia (VIN)