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cholangitis lenta

Monday 26 March 2018

Definition: Cholangitis lenta, also known as ductular cholestasis, cholangiolar cholestasis, or subacute nonsuppurative cholangitis, is an uncommon type of cholangitis characterized by ductular reaction with inspissated bile in dilated ductules.

The finding of cholangitis lenta on liver biopsy is thus frequently associated with sepsis and with a high mortality rate. Therefore, accurate diagnosis of this condition on liver biopsy is imperative as it is an indication that the patient may have a potentially life threatening condition that requires immediate medical attention and management.

Open references

- Cholangitis Lenta: A Clinicopathologic Study of 28 Cases. Torous VF, De La Cruz AL, Naini BV, Wang HL. Am J Surg Pathol. 2017 Dec;41(12):1607-1617. doi : 10.1097/PAS.0000000000000959 PMID: 28984672 Free